In dermatology, PRP and PRF treatments are both used to rejuvenate the skin and promote collagen production, but they differ in the way they are prepared and the specific applications for which they are used. We broke down these difference to help you decide which treatment may be best for you.

PRP (Platelet-Rich Plasma) treatment involves taking a small amount of the patient’s blood, processing it in a centrifuge to separate the plasma from the red and white blood cells, and then injecting the plasma into specific areas of the face or body, such as the; under eyes, lips, smile lines. The plasma contains high concentrations of platelets, which are rich in growth factors that stimulate collagen production and skin rejuvenation.

PRF (Platelet-Rich Fibrin) treatment is similar to PRP, but the processing method is slightly different. In PRF, the blood is also drawn from the patient, but with PRF treatments, the blood is spun at a lower speed so that some of the white blood cells, stem cells, and fibrin remain in the platelet layer. The slow spin also means fewer cells are damaged which leaves a higher concentration of healing platelets. PRF contains approximately 10 times the platelet concentration that is found within the body, whereas PRP contains roughly 2-5 times.  The fibrin matrix is then used for injections or as a topical application to stimulate collagen and elastin production and skin rejuvenation.

One of the main differences between PRP and PRF treatments is the composition of the injected substance. PRP injections are composed mainly of plasma, while PRF injections contain a higher concentration of platelets and white blood cells, which can enhance the regenerative properties of the treatment. The final difference is how the treatments can be used. PRP is typically performed as a facial or microneedling session while PRF is used similar to filler. The fibrin and slow-release growth factors in PRF build natural volume in the skin, so this natural filler is a wonderful alternative to synthetic filler.

Overall, both PRP and PRF treatments can improve the appearance of fine lines, wrinkles, skin elasticity, skin texture as well as help with skin rejuvenation, scar reduction and hair loss. Want to know more? Call our office to schedule a complimentary consultation!

Author Weimin Hu MD, PhD Board Certified Dermatologist Mohs Surgeon Aesthetic Dermatologist

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